Throughout the game's story, there are multiple characters who have pelo Persona power of their own but appear in the Metaverse in their copyright Thief forms and join the battles. These characters are cognitive manifestations created by Merope in accordance with the following conditions:

With a compelling plot, unique characters, and exciting gameplay, everything you've come to know and love from the Persona series is awaiting you in this new adventure!

Like Persona 5, the dungeon crawling portion takes place in the Metaverse, a realm created from subconscious desires that consists of Mementos and Palaces.

Lufel explains that humanity's hopes and desires are being stolen, including Nagisa's. While attempting to leave the Metaverse, the pair are attacked by Shadows, creatures formed from warped desires who attack humans on sight. Nagisa awakens his Persona, Jápelošík, and is able to defeat the shadows with Lufel's help, allowing them to return to the real world.

The game begins in a similar vein to how Persona 5 begins, midway through the infiltration at Niijima's Palace. However, when Joker begins to make his escape, a hooded intruder intervenes and attacks him.

Lufel points out to Nagisa a former baseball player, Takeyuki Kiuchi, who intentionally rams into women in the subway as a means of attaining his misogynistic desires, and says that in order to stop him, they must enter Kiuchi's palace (a baseball stadium) within the Metaverse and steal his treasure, an object which is the source of warped desires.

Daisoujou wearing a mask and his skeletal body has been changed to have a more flesh-like appearance.

Nagisa and Lufel enter Kiuchi's palace and discover that Motoha also entered the palace, who awakens to her Persona after being verbally berated by a Shadow Persona 5 The copyright X form of Kiuchi. While traversing through Kiuchi's palace, they discover that Motoha hitting a slider thrown by a Kiuchi, along with a scandal resulting from Kiuchi's purchasing of an escort, forced him off of the baseball team and into an office job, leading to his misogynistic desires.

Currently, mission 3 is the longest main story mission content due to had two different major targets within one shared Palace.

Regarding Kira merely as an unprofessional freshman and prioritizing his career, he obstinately refuses Kira's request to give surgery to the patient and even ignores the patient's will after the patient has made up his mind.

There are current development plans to release in other regions such as North America with localization. This release is to be followed by console releases of the game as well, with PC and phones remaining the primary platforms.

After the scene ends, it is revealed that it was just a nightmare that the protagonist had. After waking up from the dream, he makes his way to school and a mysterious owl proceeds to follow him.

In the Japanese demo shown at Tokyo Game Show 2024, the cutscenes were altered to show blood in the protagonist's awakening much like how the awakening in Persona 5 were handled.

After Miyu ran away from home, they manage to locate where she is and hire a man to sabotage her performance, later even forcibly canceling the street performer event that Miyu wants to perform at because they don't support Miyu's dream.

During class, the protagonist struggles to stay awake and drifts off. Once he awakens, he finds himself within the Velvet Room, and is welcomed in by Igor and Merope.

P5X altered the design of some Personas from the base Persona 5 to be less sexual due to censorship regulations in China (however, other versions of the game feature the uncensored designs, with some exceptions such as the Riders having metallic arms):